Gene Mutations

  • Gene mutations can arise during DNA replication.
  • Types of gene mutations include addition, deletion, substitution, inversion, duplication, and translocation of bases.
  • Gene mutations occur spontaneously, but can be increased by mutagenic agents.
  • Mutations can result in a change in the amino acid sequence of the encoded polypeptide.
  • Some gene mutations only change one triplet code, but not all result in a change in the encoded amino acid.
  • Some gene mutations result in a frame shift, changing all base triplets downstream from the mutation.
  • It is important to understand the nature of a gene mutation and its effect on the encoded polypeptide for a comprehensive understanding.