Core topics

Core topics

Biochemistry

Fundamentals of Biochemistry

  • Biochemistry explores the chemical processes within and related to living organisms.
  • This branch of science combines biology and chemistry, using chemical knowledge and techniques to help understand and solve biological problems.
  • At its core, biochemistry looks at the molecular mechanisms by which genetic information encoded in DNA is able to result in the processes of life.

Molecules in Biochemistry

  • Biochemistry is concerned with the breakdown of large, complex molecules into smaller ones, such as amino acids, nucleotides, sugars and fatty acids.
  • Proteins, which are constructed from amino acids, are considered the workhorse molecules of life; they form enzymes that speed up chemical reactions in the body.
  • Nucleotides form the basis of the body’s genetic code, encoded in DNA and RNA.
  • Sugars and fatty acids are the body’s key sources of energy.

Metabolism

  • Metabolism is a key aspect of biochemistry; it’s all about the chemical reactions in the body that maintain life.
  • Metabolism is split into two processes: anabolism, which is the building up of compounds, and catabolism, which is the breaking down of compounds.
  • The Citric Acid Cycle, also known as the Krebs cycle, is a key part of metabolism. It involves the oxidation of acetyl CoA to produce ATP, which provides energy for biological processes.

Proteins and Enzymes

  • Proteins are structurally, functionally, and biochemically incredibly diverse, making them key to many biochemical processes.
  • Enzymes, a particular class of proteins, are crucial for catalysing biochemical reactions.
  • These biocatalysts lower the activation energy of reactions, increase reaction rates and are highly specific to their substrates.

Biological Pigments

  • Biological pigments, or biochromes, are substances produced by living organisms that have a colour due to selective colour absorption.
  • These pigments play important roles in various biological activities, including photosynthesis in plants and vision in animals.

Vitamins and Cofactors

  • Vitamins are essential nutrients the body cannot synthesize in sufficient quantities and must be obtained from diet or supplements.
  • They often work as cofactors or coenzymes, acting together with enzymes to enhance their functions and catalyse metabolic reactions.

DNA and RNA

  • DNA and RNA are the macromolecules that carry genetic information in all living cells.
  • The primary function of DNA is to store and transmit the genetic information that dictates the organization and function of cells.
  • RNA, on the other hand, translates the genetic information contained within DNA to create the proteins that carry out cellular activities.