Introduction to biochemistry
Introduction to Biochemistry
Basic Understanding
- Biochemistry is the science that combines both biology and chemistry, focusing on the chemical processes occurring within and related to living organisms.
- It provides a molecular view of life, understanding how a sequence of genetic information encoded in DNA leads to the various life processes.
Key Molecules in Biochemistry
- Biochemical processes often involve breaking down large, complex molecules such as proteins, nucleic acids, carbohydrates, and lipids into their simpler units.
- Amino acids are small molecules that combine to form proteins - a diverse group of molecules that perform a large variety of functions within the organism.
- Nucleotides are the building blocks of nucleic acids - DNA and RNA.
- Sugars and fatty acids are mainly used by organisms for energy storage and metabolism.
Enzymes and Metabolism
- Enzymes, which are proteins, act as biocatalysts to speed up biochemical reactions in an organism.
- They lower the activation energy of reactions and increase reaction rates.
- Metabolism, a crucial part of biochemistry, is comprised of two counter-balancing processes: anabolism, where complex molecules are built from simpler ones, and catabolism, where complex molecules are broken down into simpler ones.
- The Citric Acid Cycle (or Krebs cycle), a central metabolic pathway, converts acetyl CoA, derived from carbohydrates, fats, and proteins, into ATP, the main energy currency in biological systems.
Biological Pigments
- Biological pigments or biochromes give colour to living organisms, and play a key role in various life-enabling processes such as photosynthesis and vision.
Vitamins and Cofactors
- Vitamins are essential micronutrients which support normal metabolism but cannot be synthesised by the body in sufficient amounts.
- They often act as cofactors or coenzymes, aiding enzymes in their functions, and facilitating metabolic reactions.
Genetic Materials: DNA and RNA
- DNA and RNA, the genetic materials found in all living cells, encode instructions for life and its processes.
- DNA’s primary function is to store and transmit the genetic information that controls cellular structure and function.
- RNA translates the genetic information in DNA to produce proteins, enabling various cellular activities.