Introduction to biochemistry

Introduction to Biochemistry

Basic Understanding

  • Biochemistry is the science that combines both biology and chemistry, focusing on the chemical processes occurring within and related to living organisms.
  • It provides a molecular view of life, understanding how a sequence of genetic information encoded in DNA leads to the various life processes.

Key Molecules in Biochemistry

  • Biochemical processes often involve breaking down large, complex molecules such as proteins, nucleic acids, carbohydrates, and lipids into their simpler units.
  • Amino acids are small molecules that combine to form proteins - a diverse group of molecules that perform a large variety of functions within the organism.
  • Nucleotides are the building blocks of nucleic acids - DNA and RNA.
  • Sugars and fatty acids are mainly used by organisms for energy storage and metabolism.

Enzymes and Metabolism

  • Enzymes, which are proteins, act as biocatalysts to speed up biochemical reactions in an organism.
  • They lower the activation energy of reactions and increase reaction rates.
  • Metabolism, a crucial part of biochemistry, is comprised of two counter-balancing processes: anabolism, where complex molecules are built from simpler ones, and catabolism, where complex molecules are broken down into simpler ones.
  • The Citric Acid Cycle (or Krebs cycle), a central metabolic pathway, converts acetyl CoA, derived from carbohydrates, fats, and proteins, into ATP, the main energy currency in biological systems.

Biological Pigments

  • Biological pigments or biochromes give colour to living organisms, and play a key role in various life-enabling processes such as photosynthesis and vision.

Vitamins and Cofactors

  • Vitamins are essential micronutrients which support normal metabolism but cannot be synthesised by the body in sufficient amounts.
  • They often act as cofactors or coenzymes, aiding enzymes in their functions, and facilitating metabolic reactions.

Genetic Materials: DNA and RNA

  • DNA and RNA, the genetic materials found in all living cells, encode instructions for life and its processes.
  • DNA’s primary function is to store and transmit the genetic information that controls cellular structure and function.
  • RNA translates the genetic information in DNA to produce proteins, enabling various cellular activities.