Tissue Investigation and Consequences of Diagnosis

Tissue Investigation and Consequences of Diagnosis

Tissue Investigation

Sample Collection

  • Samples for tissue investigation can be collected through procedures such as biopsies, surgical excisions, and aspirations.
  • A key role of biomedical scientists is ensuring these samples are collected appropriately and stored correctly to maintain cell structure and tissue integrity.


  • Histopathology involves studying changes in cells and tissues as a result of disease.
  • Techniques include fixation, to preserve tissue structure; sectioning, to create thin slices of tissue; and staining, which helps to highlight specific cellular components.
  • Histopathologic studies can identify abnormalities like inflammation, cancer, and infections.


  • Cytopathology focuses on the study of cells in disease.
  • Samples for cytopathological examination can come from body fluids or directly from tissues.
  • This science allows for the identification of malignancies and inflammatory conditions, among other diseases.

Consequences of Diagnosis

Diagnostic Accuracy

  • The accuracy of tissue investigations is critical, since diagnoses directly influence the treatment plan a patient receives.
  • Incorrect tissue investigation can lead to misdiagnoses, potentially resulting in inappropriate or delayed treatment.

Patient Anxiety

  • The process of tissue investigation and waiting for a diagnosis can cause significant patient anxiety.
  • Clear communication and timely delivery of results are essential to mitigate this.

Treatment Implications

  • Once a diagnosis is made, a series of potential treatments may be considered.
  • These can range from conservative management and monitoring through to surgical intervention, radiotherapy or chemotherapy
  • The type of tissue disorder, its severity, its progression, and the patient’s overall health all impact the chosen course of treatment.


  • A diagnosis from tissue investigation gives an indication of the probable course and outcome of a disease - the prognosis.
  • Information from tissue investigation can also be used to stage a disease, which refers to the extent of the disease within the body.
  • Understanding the severity and progression of the disease helps healthcare professionals provide a more accurate prognosis, enabling better treatment planning.